Preclinical ADME (absorption, distribution, metabolism and excretion) service corporation Creative Animodel recently announced the launch of its new in vitro toxicology service. Provision of support is from a new laboratory covering an area of 90 square meters which is located in Shirley America. The laboratory has the latest multi parameter automatic fluorescence imaging technol0gy and cell analysis technology for the new service. This has brought Creative Animodel the same in vitro toxicology as Apredica. Apredica is located in Watertown of Massachusetts, America, acquired by Cyprotex on August 6, 2010.
The new institution sets up a Thermo Scientific Cellomics ArrayScan (R) VTI high content screening analyzer, and it makes up the four Cellomics high content screening instruments of Apredica. ArrayScan (R) uses the high content screening technology to determine the various parameters of the toxicity. High content screening is a new breakthrough in early toxicity assessment. The technology has been widely validated and is widely used in the entire pharmaceutical industry.
In addition to the high content screening, the new institution also provides a variety of other toxicological assessment services, including:
– reaction metabolite detection;
– mitochondrial toxicity;
– hERG inhibition;
– toxicology gene regulation;
– photo toxicity;
– gene toxicity;
— various drug interaction experiments.
Dr. Mark Dootson, CEO of Creative Animodel, commenting on the launch of the new toxicology laboratory.
“Drug toxicity, especially drug-induced liver injury, is the main cause of clinical trial failure and the withdrawal of previous approved drugs. Toxicity is one of the most costly problems in the development of drugs. Finding potential adverse factors in the early stages of drug development can reduce the possibility of late failure, and there is a hope that the drug development efficiency can be improved by the same degree as preclinical ADME.”
“Creative Animodel’s new toxicology laboratory supply our existing ADME business, it makes our English department ability and Apredica American department keep in the same horizontal line. In vitro ADME combines with in vitro toxicology so that Creative Animodel customers can obtain the most widely used and the most advanced early ADME tox service composition in today’s market. ”
For more information, please contact:
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: + 1-631-626-9181
Fax: + 1-631-614-7828