As the abbreviation form of Transcription Activator-like Effectors, TALENs are artificial restriction enzymes which are produced through fusing a TAL effector DNA binding domain to a DNA cleavage domain. In other words, TALENs are proteins that bind to DNA in a sequence-specific way. TALENs are also used to mediate multiple genetic manipulation. There are several examples, for instance gene targeting as well as gene site-specific insertion or correction.
To be more specific, they can be generated to bind any targeted DNA sequence in a fast and efficient manner. With this technology, researchers can engineer restriction enzymes that are specific for any targeted DNA sequence through combining an engineered TALE with a DNA cleavage domain. On the other hand, those restriction enzymes are useful for genome editing in situ after they have been introduced into cells.Transcription activator–like effectors
Due to their features and advantages, such as easy to use, time-saving, effortless, as well as trusted results, TALENs can be taken into practice for transfection, genome editing, gene modification, etc. As a novel technology, Transcription Activator–like Effectors (TALE) technology is commonly used. Although it has been developed in recent years, TALE technology can achieve more scientific results with its potential development ability.
With extensive experience of operation, Creative Animodel can provide TALENs products and services, successfully generated over 50 custom models and provided services to researchers and developers at about 28 institutions all over the world. Moreover, a series of high quality TALENs services, including design, synthesis, validation and support, are available to optimize success rates of all your gene editing projects at Creative Animodel.
All in all, TALENs technology has become a powerful approach for genome editing in a number of animal models. Scientists of Creative Animodel will make more breakthroughs by improving this unique technology and others. Aiming at serving more scientists by advanced TALEN technology, Creative Animodel will continue to search new methods to realize every scientist’s research needs. For more information about TALENs, please visit http://www.creative-animodel.com/Animal-Model-Development/Custom-TALENs-Services or directly email at info@Creative-Animodel.com.